Full Thickness Placental Allograft
Full-thickness placental allograft — amnion, intermediate layer, and chorion — delivering a comprehensive biologic barrier for acute and chronic wound applications. HCPCS: Q4301.
The Innovation
From Generous Gift to Clinical Breakthrough
Natural. Protective. Proven.
Placental membranes represent a naturally preserved extracellular matrix, formed over nine months of gestation and rich in growth factors and cytokines that help support and protect fetal development.
Human Placental Membranes
Sequence LifeSciences’ placental membrane products are derived from donated human placenta following normal c-section deliveries. The placenta, previously discarded following delivery, is a biologically derived, newly formed extracellular matrix (ECM)….essentially a neomatrix.
Membrane Anatomy
About The Layers
The various layers of the placenta play a critical role during pregnancy, cushioning and forming a protective barrier around the developing fetus.
The placental extracellular matrix is composed of structural proteins and inherent biological components that contribute to this protective function. As a tissue allograft, placental membranes serve as a protective barrier, providing coverage and separation of tissues consistent with their native role.
Clinical Evidence
Research and clinical studies going back over a century have exhibited the beneficial effects of utilizing human placental membranes to manage various types of wounds due to injury, disease, or surgical intervention.
Broadly, the placental membranes include an internal or fetus facing amnion and an external or maternal facing chorion. The physical and biochemical properties of the two primary membranes are subtly different owing to the position they occupy in the placenta. The amnion is a thinner yet more compact layer of extracellular matrix while the chorion is a slightly thicker but less compact matrix. Both layers are constituted of collagen fibers (predominantly Types I, III, IV and V), along with other ECM proteins (including laminin, fibronectin, proteoglycans and hyaluronic acid) plus numerous growth factors and cytokines (1, 2).
The structural and biochemical properties of placental tissue including extracellular matrix proteins, growth factors and anti-inflammatory cytokines make this tissue an ideal starting material for Sequence LifeScience’s placental membrane products.
Our Products
Sequence LifeScience Placental-Derived Allograft tissues are prepared using our AlloKleen™ Process
The AlloKleen Process was developed to maintain the structural integrity of the tissue while removing unwanted immunogenic components in the tissue.
We do not use detergents or harsh chemicals during processing and have instituted extensive pre- and post-processing wash steps to remove unwanted extraneous tissues and fluids. This process allows the retention of key ECM components. The final step in the AlloKleen™ Process is a validated terminal sterilization process to achieve a 106 sterility assurance level (SAL) to further ensure the safety of these allograft products.
Use of our human placental allograft matrix products by qualified health care professionals is for application in a physician office, outpatient, or inpatient setting. The matrix products are indicated for a patient population with acute or chronic wounds where a biologic barrier or wound cover is required.
Products
Wound Care
Full Thickness Placental Allograft
Full-thickness placental allograft — amnion, intermediate layer, and chorion — offering a comprehensive biologic approach across a spectrum of clinical wound needs. HCPCS: Q4379.
Dual Membrane Placental Allograft
Dual-membrane allograft combining amniotic and chorionic membranes, processed using a proprietary technique. Optimized for moderate-to-deep wound beds. HCPCS: Q4350.
Amniotic Membrane Allograft
Single-layer amniotic membrane allograft processed using a proprietary technique. Thin, flexible, and designed for shallow-to-moderate wound bed applications. HCPCS: Q4348.
Amniotic & Chorionic Membrane Allograft
Dual-membrane allograft comprising amniotic and chorionic membranes of the placenta. Designed as a biologic barrier and wound cover for acute and chronic wound applications. HCPCS: Q4346.
Products
Surgical
Surgical Amniotic Membrane Allograft
Five configurations — single, dual, full thickness, and tri-layer — purpose-built for surgical applications across orthopedics, gynecology, plastic surgery, and urology.
Products
Ocular
Ocular Amniotic Membrane Allograft
Three configurations — A naturally occurring tissue with inherent structural and biological characteristics well suited for ocular surface applications.
Amniotic membrane allographs derived from human placental tissue designed to function as an ocular bandage that supports the body’s natural healing process.
In Development · 2026
Single Layer Ocular Allograft
In Development · 2026
Double Layer Ocular Allograft
In Development · 2026
Triple Layer Ocular Allograft
References
- H. Niknejad, H. Peirovi, M Jorjani, et al, “Properties of the Amniotic Membrane for Potential Use in Tissue Engineering”, Eur Cell Mater, vol. 15, pp 88-99, 2008.
- A. Roy, M. Mantay, C. Brannan, and S. Griffiths, “Placental Tissues as Biomaterials in Regenerative Medicine” BioMed Research International, vol. 2022, pp. 1-26, 2022.
